Reference of 58138-79-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58138-79-7 name is 2,6-Diiodopyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
STAGE 2: preparation of 2-iodo-6-methoxypyrazine 2,6-Diiodopyrazine (5.0 g, 15 mmol) was added to a solution of sodium methoxide in methanol (prepared from sodium (0.35 g, 15 mmol) and methanol (40 ml)) and the mixture was heated at reflux temperature for 1 hour. After cooling, the solution was diluted with water (200 ml) and extracted with diethylether (3*100 ml). The combined extracts were washed with water, dried over magnesium sulphate and concentrated under reduced pressure to give the product as a white solid (3.5 g, 100percent) m. pt. 35.7-37.2 NMR (90 MHz, CDCl3): b 8.40 (1H, s), 8.16 (1H,s), 3.98 (3H,s). m/z 236(M+), 127, 109 (100percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,6-Diiodopyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Imperial Chemical Industries, PLC; US4975112; (1990); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem