In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 486460-20-2 as follows. Safety of 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
The compound 4a (1g) (5.33 mmol) was hydrogenated at atmospheric pressure in ethanol (10 mL) using 10% Pd/C as catalyst (500 mg) at ambient temperature for 10 hour. The reaction mixture was filtered over celite and the celite bed was washed with 5 mL of ethanol and the filtrate was concentrated under reduced pressure. The obtained crude mass was passed through a small plug of silica using (5 to 8% of methanol in dichloromethane to give 0.9 g (87%) of the product as oil.
According to the analysis of related databases, 486460-20-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Nitlikar, Lakshmikant H.; Darandale, Sunil N.; Shinde, Devanand B.; Letters in Organic Chemistry; vol. 10; 5; (2013); p. 348 – 352;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem