19838-07-4, name is 3-Methylpyrazin-2(1H)-one, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Methylpyrazin-2(1H)-one
2-Hydroxy-3-methylpyrazine (14.94 g) was added to phosphorus oxychloride (55 mL) containing three drops of concentrated sulphuric acid and heated under reflux for one hour. The solution was allowed to cool to ambient temperature and then poured onto ice (600 g) and ether (300 mL). The mixture was stirred to effect hydrolysis of excess phosphorus oxychloride. Concentrated ammonia was added to adjust the pH of the mixture to 8, keeping the temperature below 10 C., the pH was then adjusted to 11 with sodium hydroxide (2M) and extracted with ether (3*300 mL). The combined organic extracts were dried (MgSO4). After removal of solvents, the residue was purified by MPLC (dichloromethane, silica) to give 2-chloro-3-methylpyrazine, (7.67 g). 1H NMR (DMSO-d6): delta2.6 (s, 3H), 8.4 (d, 1H, J=2 Hz), 8.55 (d, 1H, J=2 Hz). MS: 129 (M+H+)
The synthetic route of 19838-07-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zeneca Limited; US5843942; (1998); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem