Synthetic Route of 486460-21-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 6ATo a solution of the acid (VII’) (300 mg, 0.90 mmol) and triazolopiperazine (VIII) (170 mg, 0.90 mmol) in CH2CI2 (10 mL) is added /V-hydroxybenzotriazole (150 mg, 1 .08 mmol), and 10 minutes later, EDC (260 mg, 1 .35 mmol). The mixture, under an inert atmosphere of N2, is magnetically stirred for 4 hours until completion, then a saturated solution of sodium bicarbonate (5 mL) is added and the mixture is extracted with dichloromethane.The combined organic phases are dried and evaporated under reduced pressure. The product is purified by flash chromatography, obtaining 406 mg (86% yield) of a crystalline white solid, compound (IX’).1 H NMR (300 MHz, d6-dmso, 100 C) delta 7.4-7.2 (m, 7H), 6.90 (bs, 1 H) 4.97 & 4.90 (AB system, J= 12.9 Hz, 2 x 1 H), 4.92 (s, 2H), 4.26-4.14 (m, 3H), 3.97 (t, J=5.5 Hz, 2H), 2.92 & 2.67 (2 x dd, J=14.1 , 4.9 Hz, 2 x 1 H), 2.83-2.72 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHEMO IBERICA, S.A.; RASPARINI, Marcello; TUFARO, Roberto Rocco; MINELLI, Cosima; WO2012/150328; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem