Adding a certain compound to certain chemical reactions, such as: 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 486460-21-3, Formula: C6H7F3N4
44.0 g (0.50 mol, 1.0 eq) of 3-oxopropionic acid was dissolved in 220 g of dichloromethane solution, and N,N-dimethylformamide 0.36 g (0.021 mol, 0.01 eq) was added, and the chloride was added dropwise. Sulfuric acid 62.5g (0.525mol, 1.05eq), dripped, heated to backThe reaction was carried out for 6 hours, and the reaction of the raw material in the GC was completed. The temperature was lowered to 20 C or lower, 75.9 g (0.75 mol, 1.5 eq) of triethylamine was added dropwise, the temperature was lowered to 0 to 5 C, and 3-(trifluoromethyl)-5 was added. 1,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 114.3 g (0.50 mol, 1 eq), stirred at room temperature for 2 hours, added 60 mL of water, The layer was extracted with methylene chloride (60 g×2), and the organic layer was combined and evaporated to dryness to give a crude product, which was recrystallized from a mixture of acetone/heptane 1:3 to obtain 98.6 g of compound (III).The yield was 75.3%, and the HPLC purity was 98.6%.
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Reference:
Patent; Anhui Haikang Pharmaceutical Co., Ltd.; Zhang Xiaoshun; (9 pag.)CN108314688; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem