Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 109838-85-9
A flame-dried 100-mL round bottom flask was charged with (R)-2,5-dihydro-3,6- dimethoxy-2-isopropylpyrazine (14) (2.4080 g, 13.07 mmol) and THF (20 mt_), andI O evacuated and refilled with N2. The mixture was cooled with a dry ice-acetone bath and 2.5 M n-BuLi in hexanes (5.2 mL, 13.00 mmol) was added dropwise over 15 min. After an additional 0.5 h, a solution of 2-(3-methoxypropoxy)-4-((R)-2-(iodomethyl)-3-methylbutyl)-1- methoxybenzene (8) (3.3023 g, 8.13 mmol, 0.62 equiv) from Example 1 Step 7 in THF (20 mL) was added dropwise via cannula over 10 min. The reaction mixture was allowed to stir15 at -78°C for 16 h and quenched with brine (20 mL) at -78°C. After warming to rt, the mixture was extracted three times with ethyl acetate. The organic phase was dried over Na2SO4, filtered and concentrated in vacuo. The crude (2S,5R)-2-((S)-2-(3-(3-methoxypropoxy)-4- methoxybenzyl)-3-methylbutyl)-2,5-dihydro-5-isopropyl-3,6-dimethoxypyrazine (15) (4.85 g, 80percent) was carried on to the next step without further purification. LC-MS (3 min) tR = 2.41 0 min m/z 463 (M+H+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2007/123718; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem