Adding a certain compound to certain chemical reactions, such as: 109-08-0, name is 2-Methylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-08-0, Recommanded Product: 109-08-0
To a solution of2-methylpyrazine (272 mg, 2.9 mmol) and HMPA (520 mg, 2.9mmol) in THF (2.5 mL) was added LDA (1.6 mL, 3 mmol) at -78°C dropwise. The mixture wasallowed to stir at -78°C for 30 minutes before a solution oflnt 7-2 (600 mg, 2.45 mmol) in 2 mLof THF was added. The mixture was allowed to warm to room temperature for 3 hours before it10 was quenched with 10 mL of saturated NH4Cl solution. The resulting mixture was extractedwith EtOAc (3 x 10 mL) and the combined organic washings were dried over sodium sulfate,filtered and in vacuo. The resulting residue was purified using column chromatography (25percentEtOAc/ petroleum ether) to provide Int 7-3 (100 mg, 12percent). MS (ESI): mlz (M+Ht 339.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COBURN, Craig, A.; MALETIC, Milana; SOLL, Richard; LI, Chunsing; LUO, Yunfu; QI, Zhiqi; WO2014/4416; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem