In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5,7-Dichloropyrido[3,4-b]pyrazine
Intermediate 20: 1 ,1-Dimethylethyl (2S)-2-{r(7-chloropyridor3,4-6lpyrazin-5- yl)oxy1methyl)-4-morpholinecarboxylate; 1 , 1-Dimethylethyl (2S)-2-(hydroxymethyl)-4-morpholinecarboxylate (Preparation reference: WO 2009/071658) (586mg, 2.70mmol) was dissolved in N,N- Dimethylformamide (7ml_) and cooled in an ice bath to 5C under a nitrogen atmosphere. Sodium hydride 60% in mineral oil (162mg, 4.05mmol) was added portionwise over 15min. 5,7-dichloropyrido[3,4-b]pyrazine (647mg, 3.24mmol) was then added portionwise and the mixture stirred at 5C for 35min and quenched by addition of saturated aqueous ammonium chloride solution (20ml_). The solution was partitioned between ethyl acetate and water. The aqueous was re-extracted with ethyl acetate and the combined organic layers were washed with water, separated using a phase separation cartridge and the solvent removed to give a brown solid. The crude residue was dissolved in DCM and purified by silica chromatography eluting with a 12-62% ethyl acetate in petroleum ether gradient. The appropriate fractions were combined and the solvent was evaporated to give the title compound as a brown solid (917mg).LCMS (Method B): Rt = 1.12min, MH+ = 380.9
The synthetic route of 1379338-74-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Francis Louis; ATKINSON, Stephen John; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander G; SHIPLEY, Tracy Jane; WILSON, David Matthew; WATSON, Robert J; WO2012/123312; (2012); A1;,
Pyrazine – Wikipedia,
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