Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59489-71-3, name is 2-Amino-5-bromopyrazine, A new synthetic method of this compound is introduced below., Quality Control of 2-Amino-5-bromopyrazine
EXAMPLE 41B 5-Bromo-2-iodopyrazine Under N2, to the mixture of the product of Example 41A (7.50 g, 43 mmol) in DME (anhydrous, Aldrich, 200 mL) was added CsI (Aldrich, 11.20 g, 43 mmol), iodine (Aldrich, 5.52 g, 21.6 mmol), CuI (Stream, 2.52 g, 13.2 mmol) and isoamyl nitrite (34.8 mL, 259.2 mmol) at ambient temperature. It was then heated to 60 C. and stirred for 30 min. till no gas evolution was observed. After being cooled down to room temperature, the dark mixtures was poured into a flask containing EtOAc (200 mL) and saturated NH4Cl (200 mL), stirred for 10 min. The organic layer was separated and the aqueous layer was extracted with EtOAc (2*1000 mL). The combined organic solution was washed with 5% of Na2S2O3 aqueous (2*50 mL), brine (50 mL) and dried over MgSO4. The drying agents were filtered off and the organic solution was concentrated to provide the title compound. 1H NMR (300 MHz, CDCl3) delta 8.50 (d, J=1.36 Hz, 1H), 8.62 (d, J=1.36 Hz, 1H) ppm; m/z 284 (M+H)+, 286 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ji, Jianguo; Li, Tao; Lynch, Christopher L.; Gopalakrishnan, Murali; US2008/45539; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem