Application of 54608-52-5, A common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, molecular formula is C4H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred reaction mixture of 2-hydrazinopyrazine (8)(14.0 g, 0.127 mol) and sodium carbonate (16.2 g, 0.153 mol)in dichloromethane (DCM) (112 mL), the solution of trifluoroacetylchloride (18.5 g, 0.14 mol) in DCM (28 mL) wasadded slowly at 0-5 C. The reaction mixture was agitated at5-10 C until completion of the reaction that was judged byTLC. Water (140 mL) was added to the reaction mass toremove water soluble components and then it was allowedto stand to attain the partition between DCM and water.The organic layer was concentrated under atmospheric conditionsat below 45 C. The crude residue was recrystallizedfrom mixture of EtOAc:hexane to obtain 2,2,2-trifluoro-N’-(pyrazin-2-yl)acetohydrazide (9) as off-white solid (22.5 g,86.5%). 1H NMR (400 MHz; CD3OD), d, ppm (J, Hz): 7.94-8.22 (2H, m, Ar-H); 7.66 (1H, s, Ar-H). ESI-MS m/z (rel,%): 207.12 (M+H+) (100).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Mannam, Madhava Rao; Devineni, Subba Rao; Pavuluri, Chandra Mouli; Chamarthi, Naga Raju; Kottapalli, Raja Sekhara P.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 194; 9; (2019); p. 922 – 932;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem