Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C4H3BrN2
General procedure: 1,10-Phenanthroline (10.97 mg, 0.06 mmol) was added to 3-iodopyridine (94 mg, 0.46 mmol), 5 (p-TsOH salt, 100 mg, 0.30mmol), CuI (11.60 mg, 0.06 mmol), and K3PO4 (323 mg, 1.52mmol) in DMF (3 mL) at r.t. under nitrogen. The resultingmixture was stirred at 110 C for 1 d. The reaction mixture wasfiltered through a pad of Celite, and the filter cake was washedwith EtOAc (3 × 5 mL). The filtrate was concentrated to drynessunder reduced pressure to give a yellow residue which waspurified by flash silica chromatography, elution gradient 0-10%MeOH in CH2Cl2. Pure fractions were evaporated to dryness toafford 3a (49 mg, 68%) as an amorphous waxy yellow solid. Rf =0.41 (CH2Cl2-MeOH = 9:1). 1H NMR (400 MHz, CDCl3): delta = 8.56(1 H, d, J = 2.6 Hz), 8.48 (1 H, dd, J = 1.5, 4.8 Hz), 7.69 (1 H, ddd,J = 1.5, 2.6, 8.2 Hz), 7.32 (1 H, ddd, J = 0.7, 4.8, 8.2 Hz), 3.64 (2 H,s), 1.47 (7 H, s), 1.31 (6 H, s). N-H signal appeared under themethyl signal at delta = 1.47 ppm. 13C NMR (101 MHz, CDCl3): delta =174.4, 147.5, 146.8, 140.0, 133.3, 123.6, 62.5, 56.1, 49.7, 30.7 (2C), 27.9 (2 C). IR (): 3357, 3057, 2969, 2928, 1669, 1587, 1572,1467, 1434, 1402, 1347, 1302, 1283, 1246, 1206, 1173, 1151,1110 cm-1. HRMS (TOF ES+): m/z calcd for C13H19N3O [M + H]+:234.16009; found: 234.15987.
The synthetic route of 56423-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Alanine, Thomas A.; Stokes, Stephen; Scott, James S.; Synlett; vol. 28; 3; (2017); p. 357 – 361;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem