Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54608-52-5, name is 2-Hydrazinopyrazine, A new synthetic method of this compound is introduced below., Computed Properties of C4H6N4
General procedure: A mixture of heterocyclic hydrazine 1 (1 mmol) and aldehyde 2 (1.2 mmol) in AcOH (10 mL) was stirred at ambient temperature for 5 minute. Then to it was added Chromium (VI) oxide (149.9 mg, 1.5 mmol) and refluxed in a pre-heated oil bath at 110 C until the starting material was completely consumed (monitored by TLC, 10 min.). The reaction mixture was quenched with sat. NaHCO3 solution (30 ml) and extracted with EtOAc (50 ml). The organic layer was washed with water (40 ml), dried over Na2SO4 and evaporated. The resulting crude compound was purified by silica gel column chromatography (EtOAc/Hexane, 4:6 v/v), affording the pure N-fused 1,2,4-triazole 3.
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bhatt, Ashish; Singh, Rajesh K.; Kant, Ravi; Synthetic Communications; vol. 49; 1; (2019); p. 22 – 31;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem