Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59489-71-3, name is 2-Amino-5-bromopyrazine, A new synthetic method of this compound is introduced below., Computed Properties of C4H4BrN3
Sodium nitrite (0.54 g, 7.53 mmol) was added portionwise to concentrated H2SO4 (3.8 mL) at 0 C. The mixture was heated at 50 C. until all of the NaNO2 had dissolved and the mixture was again cooled to 0 C. A solution of 2-amino-5-bromopyrazine (1 g, 5.57 mmol) in concentrated H2SO4 (5.8 mL) was added dropwise to the nitronium solution. The ice bath was removed, and the mixture was warmed to ambient temperature and stirred for 15 minutes, then heated to 45 C. for 10 minutes. The mixture was cooled to ambient temperature and poured onto ice water (40 mL). The pH was adjusted to about 4 with 2N NaOH. The mixture was extracted with EtOAc (60 mL×3). The combined organic extracts were washed with water, brine, dried over Na2SO4, filtered, and the filtrate was concentrated to a yellow solid, which was triturated with hexanes to give 0.664 g (68%) of 5-bromo-2-pyrazinol (and tautomers thereof) as a yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.07 (s, 1H), 7.62 (s, 1H); LRMS (ESI), m/z 175/177 (M+H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SMITH KLINE BEECHAM CORPORATION a corporation; US2010/29650; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem