Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., COA of Formula: C4H5N3
To a solution of pyrazin-2-ylamine (2. 0 g, 21. 03 mmol) in dry DICHLOROMETHANE (120 mL) at 0 C, was added N-BROMOSUCCINIMIDE (3. 74 g, 21. 03 mmol) slowly to maintain the internal temperature below 0 C. The mixture was stirred at the same temperature for 24 hours, and then washed with saturated aqueous sodium bicarbonate (30 mL) and water (30 mL). The combined aqueous extracts were extracted with DICHLOROMETHANE (3 x 100 mL). The combined organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to afford the crude product. The residue was purified by flash column chromatography (10% to 50% ethyl acetate/hexanes) to yield the title compound (2. 57 g, 70%) as a yellow solid. LRMS (m/z) : 174 (M)-. ‘H NMR (CDCI3, 300 MHz) : 8. 08 (1H, d, J= 1. 3 Hz), 7. 76 (1H, D, J= 1. 3 Hz).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem