Some common heterocyclic compound, 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, molecular formula is C6H7F3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
At room temperature, a 50 ml three-necked flask was charged with F (2.6 g) prepared by the oxidation reaction ,J (1.9 g), DMF (20 ml), HOBT (0.22 g), N, N-diisopropylethylamine (2.6 ml). After the reaction solution was reduced to -15-15 C, EDC (3.0 g) was added and stirring was continued at -10-5 C for 30 minutes to 120 minutes. After the reaction solution was warmed to room temperature, the reaction was continued for 1 to 5 hours. Then, 50ml of ethyl acetate and water were added, stirred well, and separated. The aqueous layer was extracted once with 30ml of ethyl acetate. The organic layers were combined, washed with 30ml of water and concentrated to obtain G4.41g as an off white solid with a molar yield of 84.2%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 486460-21-3, its application will become more common.
Reference:
Patent; Chengdu Qianxilai Pharmaceutical Technology Co., Ltd.; Chen Shaowu; Yang Renming; (14 pag.)CN105017099; (2017); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem