Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153800-11-4, name is 2-Ethynylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 153800-11-4
A reaction flask was charged with (2R,4S,4aS)-9,10-difluoro-8-iodo-2,4-dimethyl-2,4,4a,6- tetrahydro-lH,leta-spiro[[l,4]oxazino[4,3-a]quinoline-5,5′-pyrimidine]-2′,4′,6′(3eta)-trione(Intermediate 89(b), 350 mg, 0.71 mmol), copper(I) iodide (6.78 mg, 0.04 mmol) and dichlorobis(triphenylphosphne)palladium (II) (25.01 mg, 0.04 mmol) in acetonitrile (3 ml) underN2. The flask was degassed and backfilled 3 times with a balloon containing a 50:50 mixture ofArgon/H2. TEA (0.794 ml, 5.70 mmol), which had been degassed by bubbling Ar through for 20 minutes, was added. A solution of 2-ethynylpyrazine (119 mg, 1.14 mmol) in 1 ml CH3CN that had been degassed by bubbling Ar through for 5 minutes, was added. The reaction mixture was heated to 90 0C (external temperature) under the N2/H2 balloon atmosphere for 45 minutes. The mixture was diluted with EtOAc and washed with water and brine. The combined aqueous layers were twice more extracted with EtOAc, which was washed with brine. The combined EtOAc extracts were dried and concentrated, and the residue was chromatographed on silica gel (100%CH2Cl2, followed by gradient elution to 100% EtOAc), to afford the title product as a yellow solid.MS (MH+): 468 for C23Hi9F2N5O41H NMR (300MHz, DMSO-d6) delta: 0.9 (d, 3H), 1.1 (d, 3H), 2.9 (d, IH), 3.1 (m, IH), 3.5 (d, IH),3.7-3.8 (m, IH), 3.9 (m, IH), 4.1 (d, IH), 7.1 (d, IH), 8.6 (s, IH), 8.7 (s, IH), 8.8 (s, IH), 11.6 (s,IH), 11.9 (s, IH).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 153800-11-4.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/4382; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem