Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 63286-28-2
STEP2 Preparation of Compound 8-chloro-3-((3aR,4S,6aS)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl)-[1,2,4]triazolo[4, 3-a]pyrazine To a solution of (3aR,4R,6aS)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxole-4-carbaldehyde (1.75 g, 9.3 mmol) in DCM (55 mL) was added 2-chloro-3-hydrazinylpyrazine (1.34 g, 9.3 mmol)(red suspension). The mixture was stirred at room temperature and monitored by TLC until disappearance of starting material (3 h). After cooled in ice-bath, the mixture was treated PhI(OAc)2 (4.49 g, 13.94 mmol) and stirred for 4 h at room temperature. The reaction mixture was washed with sat. aMeOH:DCM. NaHCO3 solution and brine, dried over Na2SO4 and filtered. The organic layer was concentrated in vacuo to purified by MPLC on SiO2 (Hexanes:EtOAc=9:1 to 1:1) to give 8-chloro-3-((3aR,4S,6aS)-2,2-dimethyltetrahydrothieno[3,4-d][1,3]dioxol-4-yl)-[1,2,4]triazolo[4, 3-a]pyrazine (28.6 g, 89%) as a yellow oil. 1H-NMR (CDCl3, 400 MHz): delta 7.85 (d, J=4.4 Hz, 1H), 7.75 (d, J=4.8 Hz, 1H), 6.55 (brs, 1H), 5.67 (d, J=5.6 Hz, 1H), 5.28 (m, 1H), 4.82 (t, J=4.4 Hz, 1H), 4.56 (s, 1H), 2.98 (d, J=2.8 Hz, 2H), 1.59 (s, 3H), 1.41 (s, 3H).
The synthetic route of 63286-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HANDOK INC.; Lee, Jin-Hwa; Kim, Seung-Yong; Kim, Do-Ran; Ahn, Koo-Hyeon; Lee, Gwi-Bin; Kim, Doo-Seop; Hwang, Hyun-Sook; (74 pag.)US2017/204101; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem