Adding a certain compound to certain chemical reactions, such as: 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24241-18-7, Recommanded Product: 2-Amino-3,5-dibromopyrazine
Zinc powder (235 mg, 3.6 mmol) and iodine (12 mg) were mixed under nitrogen and DMF was added. The mixture was stirred at room temperature until the color of the iodine disappeared. Benzyl bromide (0.57 mg, 3 mmol) was then added and the mixture was stirred at 80 ° C for about 3 hours. After the reaction mixture had cooled to room temperature, 2-amino-3,5 dibromopyrazine (506 mg, 2 mmol) and triphenylphosphine palladium dichloride (70 mg, 0.1 mmol) were added. Reaction at room temperature for 24 hours. The reaction mixture was filtered through celite and extracted with ethyl acetate. The ethyl acetate phase was washed with saturated sodium chloride solution. The ethyl acetate phase was dried over anhydrous sodium sulfate, filtered and purified by silica gel column chromatography on 200-300 mesh, The intermediate compound 1-1 was 313 mg of yellow solid with a yield of 59percent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-3,5-dibromopyrazine, and friends who are interested can also refer to it.
Reference:
Patent; Shandong University; Li Minyong; Du Lvpei; Jiang Tianyu; (37 pag.)CN105968114; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem