Synthetic Route of 41110-29-6, A common heterocyclic compound, 41110-29-6, name is Methyl 3-methylpyrazine-2-carboxylate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred suspension of methyl 3-methylpyrazine-2-carboxylate (3.6 g, 24 mmol) in benzotrifluoride (71 mL) was added I ,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione (3.7 g, 13mmol) and 2,2-azodiisobutyronitrile [AIBN] (0.39 g, 0.34 mL, 2.4 mmol). The reaction was heated to reflux and monitored by LCMS. After 4 h, LCMS analysis showed consumption of starting material. The reaction was allowed to cool and then concentrated in vacuo. The crude product was purified by flash column chromatography to give the desired bromide (3.6 g, 16 mmol, 66 %) as a yellow oil.1H-NMR (400MHz, CDCI3): oe = 8.72 (d, J=2.3 Hz, 1H), 8.65 (d, J=2.3 Hz, 1H), 5.04 (s, 2H), 4.12 -4.02 (m, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SHANAHAN, Stephen Edward; O’RIORDAN, Timothy Jeremiah Cornelius; (60 pag.)WO2016/174073; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem