Application of 25710-18-3, A common heterocyclic compound, 25710-18-3, name is 2,3-Dichloropyrido[2,3-b]pyrazine, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A slurry of 2,3-Dichloropyrido[2,3-b]pyrazine (Intermediate F step 2) (500 mg, 2.500 mmol), 3- fluoro-4-methylphenylboronic acid (847 mg, 5.50 mmol),tetrakis(triphenylphosphine)palladium(0) (173 mg, 0.150 mmol) and potassium carbonate (1520 mg, 1 1 .00 mmol) in dioxane (20 ml) was degassed by bubbling nitrogen through (x3). The reaction mixture was heated using microwave radiation under nitrogen at 150 °C for 4h. The resulting mixture was partitioned between EtOAc and water. The organic portion was separated, dried (sodium sulphate), filtered and concentrated in vacuo. The crude product was purified by chromatography on silica eluting with 0-3percent THF in DCM to afford the title compound;LCMS; Rt 1 .28 mins MS m/z 348 [M+H]+ Method 2minl_C_v003
The synthetic route of 25710-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; CHARLTON, Steven, John; LEBLANC, Catherine; MCKEOWN, Stephen, Carl; WO2012/7539; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem