Synthetic Route of 59489-71-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59489-71-3 as follows.
General procedure: To a dioxane solution (6.0ml) of 2-amino-3,5-dibromopyrazine 7 (304mg, 1.20mmol) was successively added tetrakis(triphenylphosphine)palladium (112mg, 9.6×10-5mol, 8mol%), 4-trifluoromethylphenylboronic acid 8a (230mg, 1.21mmol), and 1ml of 2-moldm-3 sodium carbonate under argon atmosphere. The mixture was then refluxed for 4h under argon atmosphere. After cooling to room temperature, water (10ml) was added, and organic materials were extracted using chloroform (15ml×3). The combined organic layer was then dried over sodium sulfate. The removal of the solvent afforded brown solid, which was purified by preparative thin-layered chromatography on Merck silica gel (particle size, 5-40mum; 200×200×1.75mm, 5 plates) with a mixed solvent system (ethylacetate:hexane=8:3) as a mobile phase to give 9a (293mg, 77%) in the form of a pale yellow solid and 10a (17mg, 4%) in the form of a pale yellow solid.
According to the analysis of related databases, 59489-71-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Saito, Ryota; Hirano, Takashi; Maki, Shojiro; Niwa, Haruki; Journal of Photochemistry and Photobiology A: Chemistry; vol. 293; (2014); p. 12 – 25;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem