Synthetic Route of 4858-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2,3-dichloropyrazine (I-94) (45 g, 300 mmol) in NuEta3·Eta20 (1000 mL) was stirred at 120 C in a 2 L autoclave overnight. The mixture was filtered, and the filter cake was washed with water (400 mL) and CH2CI2 (400 mL), and dried in vacuum to afford 2-amino-3-chloropyrazine (I-95) (36.85 g, 94%) as a gray solid, which was used directly without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem