Application of 5900-13-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Toa solution of 5-bromo-3-methoxypyrazin-2-amine (500 mg, 2.45 mmol) in pyridine(5 mL) at room temperature was added 3-chlorophenyl)methanesulfonyl chloride(552 mg, 2.45 mol) over 5 min. The mixture was stirred 10 mins, the pyridineevaporated, then DCM (60 mL) and water (10 mL) was added. The phases wereseparated and the organic phase was washed with brine (5 mL), dried (Na2SC>4),the mixture filtered and the filtrate evaporated to dryness to afford an orangeoil which was chromatographed on silica (Heptane: EtOAc 1 :1) to afford thetitle compound as a light brown solid (483 mg, 48%); m z=393.7, 395.7 (MH)+.
The synthetic route of 5-Bromo-3-methoxypyrazin-2-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem