Adding a certain compound to certain chemical reactions, such as: 6924-68-1, name is Ethyl pyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6924-68-1, Formula: C7H8N2O2
Ethyl pyrazine carboxylate (4.0 g, 13.14 mmol) in 200 mL of DCM was treated at O0C with meta-chloroperbenzoic acid (57- 80%, 5.67 g). The mixture was allowed to warm to ambient temperature and stirred for 72 h, when an additional 4.28 g of meta-chloroperbenzoic acid was added. After an additional 4 d, 6 mL of acetone was added and stored for 2.5 d. Then 2.2 g of sodium metabisulfite in 5 mL of water was added and stirred for 2 h. Ethyl acetate was added and the mixture was washed with brine, dried over sodium sulfate, filtered and concentrated to leave a solid which was purified by chromatography (silica gel, elution with ethyl acetate/pentane), affording 3.35 g of the N-oxide. The N-oxide thus prepared (2.0 g, 11.89 mmol) in 10.53 mL of phosphorous oxychloride and 18 mL of toluene was heated at 100C for 1.5 h. The mixture was carefully treated with ice and then with saturated aqueous sodium carbonate solution. The product was extracted into ethyl acetate, and the combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (elution with ethyl acetate/pentane) to give 1.27 g of 6-chloro-pyrazine-2- carboxylic acid ethyl ester. .
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Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/86705; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem