These common heterocyclic compound, 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Aminopyrazine-2-carbonitrile
To a suspension of 5-aminopyrazine-2-carbonitrile (750 mg, 6.22 mmol) in THF (10 mL) was added sodium hydride (420 mg, 10.36 mmol) at O5 C. The resulting mixture was then stirred at ambient temperature for 1 h. Compound 305-6 (1.7 g, 5.18 mmol) was added and stirred at 60 C for 4 h. The reaction mixture was quenched with ice-water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over Na2SO4 and concentrated. The crude product was purified by column chromatography (hexanes/ethyl acetate: 5/1) to afford the title compound 306-6 as a yellow solid (1.0 g, 50% yield). LCMS:401.1[M+1]. ?HNIVIR (400 1VIHz, CDC13): 2.34 (s, 3H), 2.36 (s, 3H), 3.46 (s, 3H), 3.81 (s, 3H), 5.16 (s, 2H), 5.69 (s, 1H), 6.46 (s, 1H), 6.63 (s, 1H),8.37 (d, J= 1.2 Hz, 1H), 8.52 (d, J= 1.6 Hz, 1H),14.64 (s, 1H).
The synthetic route of 5-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
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