Related Products of 143591-61-1,Some common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2 2-(3-Bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol 3-Bromo-8-chloro-imidazo[1,2-a]pyrazine (0.70 g, 3.0 mmol) (from Example 1 supra) was stirred in nBuOH (10 mL) and ethanolamine (0.22 mL, 3.65 mmol) followed by Hunig’s base (1.04 mL, 6.0 mmol) Reaction mixture was then heated at 100 C. overnight. The mixture was concentrated to dryness and water was added (150 mL) followed by a saturated aqueous solution of NaHCO3 (50 mL). The reaction was then extracted with EtOAc (3*20 mL) and the organic phases were combined, washed with water (2*20 mL), dried over MgSO4 and concentrated to dryness to give 2-(3-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol. (Yield 0.59 g, 77%). 1H (400 MHz; DMSO-d6) delta 3.52-3.56 (2H, m), 3.58-3.62 (2H, m), 4.79 (1H, t, J=5.4 Hz), 7.42 (2H, d, J=5 Hz), 7.56 (1H, d, J=5 Hz), 7.66 (1H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; Luk, Kin-Chun; Soth, Michael; US2012/238564; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem