Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33332-29-5, name is 2-Amino-5-chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 33332-29-5
General procedure: To a solution of amines 12a-f in dichloromethane (20 mL) at 0 C was added triethylamine dropwise and the solution was stirred for 10 min. Methyl 2-(chlorosulfonyl)acetate in dichloromethane (10 mL) was added slowly at the same temperature. The reaction mixture was allowed to warm to room temperature and stirred for overnight after the addition completed. Water was added once the completion of reaction, and the mixture was stirred for 15 min. The organic layer was separated and dried over anhydrous sodium sulphate. Dried residue was evaporated under reduced pressure and was purified by flash column chromatography (silica gel, petroleum ether ramping to ethyl acetate:petroleum ether = 1:1) to give 13a-f.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33332-29-5.
Reference:
Article; Long, Yi; Yu, Mingfeng; Li, Peng; Islam, Saiful; Goh, Aik Wye; Kumarasiri, Malika; Wang, Shudong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5674 – 5678;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem