Synthetic Route of 5521-55-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
1) 5-Methylpyrazine-2-carboxylic acid N-methoxy-N-methylamide Triethylamine (28.9 mL) was added at room temperature to 5-methylpyrazine-2-carboxylic acid (13.0 g), N,O-dimethylhydroxylamine hydrochloride (10.1 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (19.8 g), and 1-hydroxybenzotriazole (14.0 g) in N,N-dimethylformamide (130 mL), followed by stirring for 63 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was dried over sodium sulfate anhydrate. After a filtration step, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane – ethyl acetate), to thereby give 5-methylpyrazine-2-carboxylic acid N-methoxy-N-methylamide as a solid product (12.3 g, 72%). 1H-NMR(400MHz,CDCl3)delta:2.63(3H,s), 3.41(3H,s), 3.74(3H,s), 8.46(1H,s), 8.82(1H,s). FAB-MS m/z:182(M+H)+.
The chemical industry reduces the impact on the environment during synthesis 5-Methylpyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Pyrazine – Wikipedia,
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