Reference of 13924-94-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13924-94-2, name is Methyl 5-aminopyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Methyl 5-aminopyrazine-2-carboxylate (8) (0.650g, 4.2483mmol) was reacted with excess of acetic anhydride (5mL) and heated at 90C for 2h. The reaction mixture was evaporated and partitioned between saturated NaHCO3 solution and ethyl acetate. Organic layer was evaporated to get 0.345g of compound 9a as pale yellow solid (yield 41.6%). 1H NMR (400MHz, DMSO-d6) delta 11.29 (s, 1H), 9.41 (d, J=1.4Hz, 1H), 8.96 (d, J=1.4Hz, 1H), 2.18 (s, 3H), 1.81 (s, 3H). C8H9N3O3 [M]: 195.18; MS (ESI) m/z: [M+H]+: 196.05 [M-H]+, 194.05
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-aminopyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Trivedi, Prakruti; Adhikari, Nilanjan; Amin, Sk. Abdul; Jha, Tarun; Ghosh, Balaram; European Journal of Pharmaceutical Sciences; vol. 124; (2018); p. 165 – 181;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem