Synthetic Route of 143591-61-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.
Intermediate Example 7-1 : Preparation of 3-bromo-N-(2- methylpropyl)imidazo[ 1 ,2-a]pyrazin-8-amineTo a stirred solution of 3-bromo-8-chloro-imidazo[1 ,2-a]pyrazine which was prepared according to intermediate example 2-1 (4 g, 17.2 mmol) in THF (54 mL) was added 4.9 mL isobutylamine (3.77 g, 51.6 mmol, 3 eq) and 7.2 mL TEA (5.22 g, 51.6 mmol, 3 eq) in one portion at rt and the mixture was heated at 140C in a microwave tube. Purification by flash chromatography yielded 4.45 g (91 %) of the title compound. 1H-NMR (300 MHz, d6-DMSO): delta = 7.64 (d, 1 H), 7.61 (s, 1 H), 7.48 (d, 1 H), 7.36 (d, 1 H), 3.24 (dd, 2H), 1.96 (m, 1 H), 0.85 (d, 6H) ppm. UPLC-MS: RT = 0.84 min; m/z 270.2 [MH+]; required MW = 269.2.
The chemical industry reduces the impact on the environment during synthesis 3-Bromo-8-chloroimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; WO2012/80229; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem