New learning discoveries about 870787-06-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its application will become more common.

Synthetic Route of 870787-06-7,Some common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, molecular formula is C6H3F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 100 mL round bottom flask was charged with the compound represented by the formula (II-1) (2 mmol), EDCI (2.4 mmol), HOBt (2.4 mmol) and 10 mL of DMF, and reacted at 25 C. for 1 h. Then, the compound (2.4 mmol) represented by the formula (II-2) was added to the above solution and reacted at 25C for 24 hours. After the solvent was removed, the target product was obtained by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its application will become more common.

Reference:
Patent; Central China Normal University; Yang Guangfu; Li Hua; Xiong Li; (34 pag.)CN108069915; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem