Adding a certain compound to certain chemical reactions, such as: 110223-15-9, name is 2-Amino-3-benzyloxypyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110223-15-9, Computed Properties of C11H11N3O
2-Bromo-4,4, 4-trifluoro-3-oxo-butyric acid ethyl ester (2.61 g, 9.9 mmol) was added to a solution of 2-amino-3-benzyloxypyrazine (Compound m in Scheme 1, 1 g, 5.0 mmol) in ethanol (10 mL). The reaction mixture was refluxed for 5 h. Upon cooling, a yellow precipitate formed from the reaction mixture. The solid was collected and washed with ice-cold ethanol to give a light yellow solid (0. 82g, 61%). 1H-NMR (CD3OD-d4) No. 8. 23 (d, J5. 9 Hz, 1H), 7.10 (d, J5. 9 Hz, 1H), 4.47 (q, J 7.1 Hz, 2H), 1.41 (t, J7. 1 Hz, 3H); MS (ES1) 276.0 ([M+H] +).
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Reference:
Patent; CARDIOME PHARMA CORPORATION; WO2005/34837; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem