Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Product Details of 91476-80-1
A mixture of (2-chloropyrimidin-4-yl)-(l -isopropyl-1 H-imidazo[4,5-c]pyridin-6-yl)amine (Example 12, step 4) (70 mg, 0.24 mmol), 5,6,7,8-tetrahydroimidazo[l,2-a]pyrazine (44 mg, 0.36 mmol), triethylamine (0.15 mL) in isopropyl alcohol (0.5 mL) was heated at 150 C under microwave irradiation on high absorbance for 2.5 h. The cooled reaction mixture was poured onto an SCX cartridge; the cartridge was washed with MeOH followed by elution of the product with 2M NH3 in MeOH. The product containing fractions were concentrated in vacuo and the resulting residue was crystallised from MeOH/EtOAc to afford the title compound as a white solid (55 mg, 62%). LCMS (ESI): RT 1.72 min, [M+H]+ 376.0, Method = E. lH NMR (400 MHz, CDC13): delta 8.75 (1H, d, J = 1.0 Hz), 8.29 (1H, s), 8.06 (1H, d, J = 5.7 Hz), 7.95 (1H, s), 7.66 (1H, s), 7.02 (1H, d, J = 1.3 Hz), 6.86 (1H, d, J = 1.3 Hz), 6.22 (1H, d, J = 5.7 Hz), 5.08 (2H, s), 4.79-4.67 (1H, m), 4.30 (2H, t, J = 5.4 Hz), 4.07 (2H, t, J = 5.4 Hz), 1.70 (6H, d, J = 6.7 Hz).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem