Synthetic Route of 4774-15-6, These common heterocyclic compound, 4774-15-6, name is 2,6-Dimethoxypyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
20 ml of 30% hydrogen peroxide was slowly added to 20 ml of acetic acid at room temperature, and then 4 g of 2,6-dimethoxypyrazine was added to the above oxidizing agent solution.After it is dissolved, the reaction system is heated to 55 C, and reacted for 4 hours; after the reaction is completed, the reaction system is cooled to room temperature and poured into ice water;The mixture was extracted 9 times with ethyl acetate.After the solid was filtered off, the filtrate was evaporated under reduced pressure to remove solvent.The white solid product 2,6-dimethoxypyrazine-4-oxide was obtained in a yield of 68%.
The synthetic route of 4774-15-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Engineering Physics Institute Chemical Materials Institute; Huang Qi; Li Hongzhen; Nie Fude; (11 pag.)CN107266376; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem