Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27398-39-6, name is 3-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 27398-39-6
To a suspension of 3-chloropyrazine-2-carboxylic acid (5.46 g) in THF (100 mL) was added CDI (6.14 g) at room temperature, and the mixture was stirred at room temperature for 30 min and heated to 50 °C. After stirring at 50 °C for 1 h, the mixture was cooled to room temperature. To the mixture were added N, O-dimethylhydroxylamine hydrochloride (5.04 g) and DIPEA (9.02 mL) at room temperature, and the mixture was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (3.05 g) .MS (API+) : [M+H]+ 202.1.H NMR (300 MHz, CDC13) delta 3.43 (3H, s) , 3.58 (3H, s), 8.44 (1H, d, J = 2.3 Hz>, 8.52 (1H, d, J = ‘2.3 Hz).
The synthetic route of 27398-39-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; RAKER, Joseph; TANIGUCHI, Takahiko; YOSHIKAWA, Masato; HASUI, Tomoaki; KUNITOMO, Jun; WO2012/18909; (2012); A1;,
Pyrazine – Wikipedia,
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