Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 939412-86-9
in a 3 L reaction flask, DCM (dichloromethane) (500 mL), intermediate 2 (39 g,217 mmol), 1148-11-4 (N-benzyloxycarbonyl-L-proline) (54 g, 217 mmol) and Et3N (87.7 g, 868 mmol) were addedsuccessively. Under nitrogen protection, the reaction solution was cooled to 0 C and HATU (2-(7-azobenzotriazole)-tetramethylurea hexafluorophosphate) (98.8 g, 260 mmol) was added in batches. The reaction solution wasnaturally warmed to room temperature, and the reaction was carried out for 14 hours under stirring. After the reactionwas completed, HCl (400 mL, 0.5 N H2O) was added, the obtained mixture was filtered through diatomite and wasextracted, the organic phase was washed with NaHCO3 (5%) and saturated saline solution, dried over Na2SO4 andconcentrated, then passed through column (PE (polyethylene): EA (ethyl acrylate) = 1:1) to obtain intermediate 3(12.7 g, yield: 14.7%) as a white solid. LCMS showed a molecular ion peak (M+1) 375.0.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Hangzhou Sanyintai Pharmaceutical Technology Co., Ltd.; Yin, Jianming; YIN, Jianming; LV, Yubin; LI, Bangliang; (36 pag.)EP3480199; (2019); A1;,
Pyrazine – Wikipedia,
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