Adding a certain compound to certain chemical reactions, such as: 74290-69-0, name is 5-Bromo-6-methylpyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74290-69-0, COA of Formula: C5H6BrN3
A suspension of 5-bromo-6-methylpyrazin-2-amine (500 mg, 2.66 mmol), sodium cyanide (1303 mg, 26.6 mmol), copper(l) cyanide (2382 mg, 26.6 mmol) in DMF (10 ml) was stirred at 120 C during 15 h. After cooling to rt, the reaction mixture was diluted with H20 (10 ml) and concentrated. The residue was partitioned between EtOAc (100 ml) and 3% ammonium hydroxide (150 ml). The aqueous layer was extracted further with EtOAc (2 x 70 ml), and the combined organic layers were washed again with 3% ammonium hydroxide (50 ml), brine (50 ml), dried (Na2S04), filtered and concentrated to give the title compound. [M+H]+ = 135.0, HPLC RtA= 0.75 min.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; NOVARTIS AG; FLOHR, Stefanie; MARKERT, Christian; NAMOTO, Kenji; PIRARD, Bernard; WO2013/111108; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem