Electric Literature of 486424-37-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 486424-37-7 name is 3-Amino-6-bromopyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
tert-Butyl (3-(3-amino-6-bromopyrazine-2-carboxamido)-2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzyl)(methyl)carbamate (9B) A stirring, room temperature solution of 3-amino-6-bromopyrazine-3-carboxylic acid (2.18 g, 10 mmol), tert-Butyl (3-amino-2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzyl)(methyl) carbamate (4.61 g, 12 mmol) and HOBt (0.68 g, 5 mmol) in DMSO (16 mL) was treated with neat EDAC (4.79 g, 25 mmol). After 3 hours the reaction mixture was treated with water (50 mL) yielding a goo. The reaction mixture liquid was decanted off and the goo was treated with additional portions of water (40 mL each), again decanting between treatments. The goo was then partitioned between EtOAc (200 mL) and water (50 mL). The resulting organic phase was washed sequentially with saturated aqueous NaHCO3, 1N HCl, and then saturated aqueous NaHCO3 once again. The organic phase was then dried over Na2SO4, filtered and concentrated under reduced pressure to give an oil. This oil was placed under high vacuum overnight to yield 4.97 g (85%) of desired product as an amber oil. LC/MS: (>95%) (weak M+H=585; stronger M+23=607).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-6-bromopyrazine-2-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Atrin Pharmaceuticals LLC; Breslin, Henry Joseph; Gilad, Oren; Sperl, Gerhard; Brown, Eric J.; Butler, Laura; (77 pag.)US2017/291911; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem