Synthetic Route of 914452-71-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 914452-71-4 as follows.
To a solution of 2-bromo-6-methylpyrazine (3 g, 17.3 mmol) in carbon tetrachloride (30 ml) were added at r.t. under an argon atmosphere N-bromo succinimide (3.39 g, 19.1 mmol) and benzoyl peroxide (420 mg, 1.73 mmol). The mixture was stirred for 24 fir, while a 75 W lamp was shining on the orange reaction mixture). The mixture was filtered, washed with CC14 and concentrated. The residue was dissolved in EtOAc, washed with sat aq NaHC03, brine, dried over MgS04, filtered and concentrated. The crude product was purified by silica gel chromatography using a heptane/EtOAc gradient as eluent, providing the title compound (1.88g, 43%) as brown solid.
According to the analysis of related databases, 914452-71-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; LERNER, Christian; WO2013/178569; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem