Application of 4744-50-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4744-50-7 name is 2,3-Pyrazinecarboxylic anhydride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1. In a (200 mL) round bottom flask, add 2,3-pyrazine dicarboxylic anhydride (1.5 g, 0.01 mol). Under protection, add 100 ml of chloroform, heat to 80 C, stir to dissolve; then add 0.2 g of N, N-diisopropylethylamine (DIPEA) and 0.15 g of 4-dimethylaminopyridine (DMAP), and 10 mL of chloroform dissolved in aza-15-crown ether was added dropwise. 5 (2.19 g, 0,01 mol), about 20 minutes. After the dropwise addition, the reaction was held for 8 hours. After the reaction was completed, the solvent was distilled off under reduced pressure. Agent, add 0.1mol / L sulfuric acid to adjust the pH to 5; add petroleum ether to extract three times. Get “competitive” fluoride ion fluorescent probes Precursor compound 3; Yield: 78%. FIG. 7 shows a synthesis route of a precursor fluoride ion fluorescent probe precursor compound in this example.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Pyrazinecarboxylic anhydride, and friends who are interested can also refer to it.
Reference:
Patent; Xihua University; Wang Huizhen; Yong Xi; Ye Maoping; Zhou Min; Li Xin; Du Bomeng; Li Tingting; (18 pag.)CN110590761; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem