Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 5-Methylpyrazine-2-carboxylic acid
100.0 g (0.724 mol) of 5-methylpyrazine-2-carboxylic acid was weighed, added to 200.0 ml of purified water, and 11.5 g (0.035 mol) of sodium tungstate was added. The temperature was raised to 45.0 C, the pH was adjusted to 9.0 with sodium hydroxide, 123.0 g (1.086 mol) of 30% H 2 O 2 was added, and the reaction was stirred for 12 h. Adjust the pH to 2.0 with concentrated hydrochloric acid, then stir to the full solution, cool to 5.0 C, and stir for 3 h. After suction filtration, 105.5 g of acipimox was obtained, the yield was 94.5%, the purity was 99.94%, and the peroxide impurity was 0.006%.
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lunan Pharmaceutical Group Co., Ltd.; Ti Wenli; Chu Yanjun; (7 pag.)CN109438369; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem