Electric Literature of 121246-96-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121246-96-6, name is 3-Chloropyrazine-2-carbaldehyde belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
A mixture of intermediate 3.3 (2.00 g, 10.4 mmol) and 3-chloro-pyrazine-2-carbaldehyde (1 .48 g, 10.4 mmol) in DMF (10.0 mL) and DMSO (5.00 mL) was stirred for 45 min at 100 C in a microwave. 1 ,1 ,1 -Triacetoxy-1 ,1 -dihydro-1 ,2-benziodoxol-3(1 H)-one (4.40 g, 10.4 mmol) was added and the mixture was stirred for 1 h at rt. The mixture was poured into H2O, filtered, washed with H2O and dried to obtain the product.MS (ESI+): (M+H)+279HPLC: RT = 0.41 min, Method F
The synthetic route of 3-Chloropyrazine-2-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; GERLACH, Kai; EICKMAIER, Christian; SAUER, Achim; JUST, Stefan; CHENARD, Bertrand L.; (86 pag.)WO2019/11802; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem