Synthetic Route of 875781-43-4, The chemical industry reduces the impact on the environment during synthesis 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, I believe this compound will play a more active role in future production and life.
In the reactor by adding 5-bromo-1H-pyrrolo [2,3-b] pyrazine (59.4 mg, 0 . 3mmol), step 5 the material 3-ethynyl-4-methyl-N-(4 – ((3-methyl -3,8-diazabicyclo [3.2.1] octane-8-yl) methyl) – 3 – (trifluoromethyl)-phenyl) benzamide (112 mg, 0 . 3mmol), bistriphenyl phosphorus palladium chloride (22 mg, 0 . 03mmol), three ring hexyl phosphine (16 mg, 0 . 06mmol), cuprous iodide (6 mg, 0 . 03mmol), cesium carbonate (99 mg, 0 . 3mmol), 6 drop N, N-diisopropyl ethylamine, for 80 C reaction under 12h. After the reaction, by adding ethyl acetate and ammonia-water extraction, and with a saturated NaCl solution, anhydrous Na 2 SO 4 drying, filtering, turns on lathe does, column chromatography purification to obtain a target compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NANJING SHENGHE PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; LIU, YANG; ZHANG, JINGZHONG; WANG, DEZHONG; GAO, YIPING; CHEN, HONGYAN; ZHANG, CANG; ZHANG, DI; (68 pag.)TWI523856; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem