Synthetic Route of 399-66-6,Some common heterocyclic compound, 399-66-6, name is [1,2,4]Triazolo[1,5-a]pyrazine, molecular formula is C5H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Platinum(IV) oxide (2.75 g, 12.1 mmol) was added, under nitrogen, to a suspension of calcium oxide (9.30 g, 166 mmol) and [1,2,4]triazolo[1,5-a]pyrazine (18.10 g, 151 mmol) in 2-methoxyethanol (150 ml). The reaction mixture was stirred for 21.5 h under a hydrogen atmosphere, filtered over Celite, and washed with dichloromethane/ethanol (9:1). The filtrate was concentrated, coevaporated with toluene and diisopropyl ether, and then dissolved in ethyl acetate, filtered over Celite, washed with ethyl acetate and concentrated again. The residue was dissolved in hot diisopropyl ether, filtered, washed with diisopropyl ether, and concentrated for 7 h in vacuo. Yield: 17.12 g (92%)
The synthetic route of 399-66-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gruenenthal GmbH; US2008/153843; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem