Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 36070-75-4
General procedure: To a solution of 9 (75 mg, 0.226 mmol) in 1,3-dimethyl-2-imidazolidinone (DMI) (0.75 mL), Et3N (0.13 mL, 0.903 mmol) and 2-chloro-5-cyanopyridine (62.6 mg, 0.451 mmol) were added, andthe mixture was then stirred at 160 C for 1 h. After cooling toroom temperature, EtOAc was added, and the mixture was washedwith H2O, dried over MgSO4, and concentrated under reduced pressure.The residue was purified by column chromatography(CHCl3/MeOH = 100/0 to 95/5) to give the title compound (46 mg,56%).
The synthetic route of 36070-75-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nakajima, Yutaka; Inoue, Takayuki; Nakai, Kazuo; Mukoyoshi, Koichiro; Hamaguchi, Hisao; Hatanaka, Keiko; Sasaki, Hiroshi; Tanaka, Akira; Takahashi, Fumie; Kunikawa, Shigeki; Usuda, Hiroyuki; Moritomo, Ayako; Higashi, Yasuyuki; Inami, Masamichi; Shirakami, Shohei; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4871 – 4883;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem