Adding a certain compound to certain chemical reactions, such as: 78342-42-4, name is (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78342-42-4, Safety of (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
Into a 500-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed (2 S)-3 , 6-dimethoxy-2-(propan-2-yl)-2, 5 -dihydropyrazine (3 g, 15.47 mmol) and THF (200 mL). A solution of n-BuLi in n-hexane (2.5 M) (9.8 mL, 24.5 mmol) was added at -80 °C in a liquid nitrogen bath. The resulting solution was stirred for 30 mm at -80°C in a liquid nitrogen bath. Then a solution of 5-(bromomethyl)-2,4-dichloropyridine (4.7 g, 18.53 mmol) in THF (lOmL) was added. The resulting solution was allowed to react, with stirring, for an additional 1 h while the temperature was maintained at -80°C in a liquid nitrogen bath. The reaction was then quenched by the addition of 120 mL of ammonium chloride (sat. aq.). The resulting mixture was extracted with DCM (2 x 150 mL) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with 1:10 ethyl acetate/pet. ether) to afford (2R,5S)- 2- [(4,6-dichloropyridin-3 -yl)methyl]-3 , 6-dimethoxy-5 -(propan-2-yl)-2, 5 -dihydropyrazine as a white solid. MS: (ESI, m/z): 344, 346 [M+H]t
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; FORMA THERAPEUTICS, INC.; ZABLOCKI, Mary-Margaret; GUERIN, David J.; NG, Pui Yee; WANG, Zhongguo; SHELEKHIN, Tatiana; CARAVELLA, Justin; LI, Hongbin; IOANNIDIS, Stephanos; (518 pag.)WO2019/32863; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem