Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19745-07-4, name is 2,5-Dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
Add [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.445 g, 0.596 5 mmol) to the suspensions ofmethyl1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenyl]cyclo propanecarboxylate (2.00 g, 5.4 mmol,), sodium carbonate (1.26 g, 11.9 mmol) and 2,5-dichloropyrazine (8.93 mmol) in 1,4-dioxane (20 mL) and water (4 mL) under N2. Then the reaction mixture is stirred at 100 oc for 3 h under N2. The reaction mixture is concentrated to give a black solid. The mixture is diluted with water (20 mL) and 10 extracted with EtOAc (30 mL x 3). The combined organic layers are washed with brine (20 mL), dried over anhydrous Na2S04, filtered and evaporated to afford the crude product. The crude product is purified by flash chromatography eluting with petroleum ether: EtOAc (1 :2) to afford title compound (1.0 g 57.6percent) as a yellow solid, LCMS (m/z): 288.9 [M+Ht. 1H NMR (400 MHz, CD3Cl) 8 = 8.80 (d, J = 1.2 Hz, 1H), 8.65 (d, J = 1.2 Hz, 1H), 7.96 (d, J 15 = 8.4 Hz, 2H), 7.51 (d, J= 8.4 Hz, 2H), 3.67 (s, 3H), 1.72- 1.66 (m, 2H), 1.28- 1.23 (m, 2H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19745-07-4.
Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; MA, Tianwei; WU, Liang; ZHANG, Xuejun; (109 pag.)WO2019/41340; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem