Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59303-10-5, name is 2-Chloro-5-methylpyrazine, A new synthetic method of this compound is introduced below., Product Details of 59303-10-5
Example 1.18: Preparation of 2-(4-(((lr,4r)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)cyclohexyloxy)methyl)piperidin-l-yl)-5-methylpyrazine (Compound 9).; A mixture of 4-(((l r,4r)-4-(2-fluoro-4- (methylsulfonyl)phenyl)cyclohexyloxy)methyl)piperidine hydrochloride (36.1 mg, 0.089 mmol), prepared in Example 1.17, Step A, 2-chloro-5-methylpyrazine (25 mg, 0.194 mmol), and triethylamine (50 muEpsilon, 0.359 mmol) in iPrOH (2 mL) was heated under microwave at 150 C for 1 h, at 200 C for 1 h, and then at 180 C for 14 h. The mixture was purified by HPLC (5- 95% CH3CN). Fractions containing the title compound were partly concentrated and the residue was extracted with 1M NaOH and CH2C12 (three times). The combined organic phases were dried over MgS04, filtered, and concentrated to give the title compound (24.1 mg, 0.052 mmol, 58.7 % yield) as a white solid. Exact mass calculated for C24H32FN3O3S: 461.21 , found: LCMS m/z = 462.4 [M+H]+; lU NMR (400 MHz, CDC13) delta ppm 1.24-1.58 (m, 6H), 1.81-1.96 (m, 5H), 2.17-2.20 (m, 2H), 2.40 (s, 3H), 2.84-2.95 (m, 3H), 3.05 (s, 3H), 3.25-3.31 (m, 1H), 3.37 (d, = 6.2 Hz, 2H), 4.25-4.28 (m, 2H), 7.40-7.43 (m, 1H), 7.58-7.60 (m, 1H), 7.66-7.68 (m, 1H), 7.95 (s, 1H), 8.06 (s, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; LEHMANN, Juerg; THORESEN, Lars; WO2012/135570; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem