The origin of a common compound about

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-58-4, name is 5-Methylpyrazin-2-amine, A new synthetic method of this compound is introduced below., category: Pyrazines

2-Amino-5-methyl-pyrazine (2.00 g, 21.25 mmol; CASNo. 5521-58-4) was dissolved in THF (80 mL), cooled to 0 0C, and treated with pyridine (1.77 g, 22.3 mmol) followed by the dropwise addition of phenylchloroformate (3.49 g, 22.3 mmol) in THF (30 mL). After stirring for 3 h, 100 mL of MeCN was added and the reaction mixture was reduced to a volume of 100 ml. in vacuo. The title compound as white crystals was collected by filtration (2.5 g, 55%) and was used without further purification.

The synthetic route of 5521-58-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2009/127948; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem