Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 76537-18-3, name is 3-Bromo-5-chloropyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
A solution of the compound 5a (2.20g, 8.00mmol), 3-bromo-5-chloropyrazin-2-amine (1.54g, 7.27mmol), potassium acetate (2.00g, 14.54mmol), Pd (dppf) Cl2 (0.15g, 0.20mmol), H2O (2mL) in dioxane (40mL) was heated to 75 C under N2 for 4 hours. Hexane (50mL) was added, the precipitate was filtered to afford the compound 5b as a brown solid (0.79g, 36%). MS: 277 (M+H) +.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 76537-18-3.
Reference:
Patent; JACOBIO PHARMACEUTICALS CO., LTD.; MA, Cunbo; GAO, Panliang; CHU, Jie; WU, Xinping; WEN, Chunwei; KANG, Di; BAI, Jinlong; PEI, Xiaoyan; (82 pag.)WO2017/211303; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem